Alpha-glucosidase inhibitory activity of some brown seaweeds collected in Nha Trang bay, Khanh Hoa province

Han T. Nguyen * , Duong T. H. Ngo , & Yen T. P. Nguyen

* Correspondence: Nguyen The Han (email: hannt@ntu.edu.vn)

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Received: 16 Dec 2019
Revised: 28 Jan 2020
Accepted: 25 Feb 2020
Published: 29 Apr 2020
DOI: 10.52997/jad.11.02.2020
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Nguyen, H. T., Ngo, D. T. H., & Nguyen, Y. T. P. (2020). Alpha-glucosidase inhibitory activity of some brown seaweeds collected in Nha Trang bay, Khanh Hoa province. The Journal of Agriculture and Development 19(2), 90-98.
Issue
Volume 19 - Issue 2 (2020)
Section
Food Science and Technology

Main Article Content

Abstract

Diabetes has become a global problem in recent years. Inhibition of α-glucosidase is one of the effective approaches to control the post-prandial blood gluccose and thereby mananging diabetes. This study evaluated inhibitory activity of seven brown seaweed extracts (Colpomenia sinuosa, Padina australis, Sargassum aquifolium, Sargassum mcclurei, Sargassum duplicatum, Sargassum polycystum và Sargassum swartzi) against α-glucosidase. The results indicated that all seaweed extracts inhibited enzyme activity with the IC50 values ranging from 154.27 to 426.27μg/mL. The seaweed Sargassum mcclurei showed the highest α-glucosidase inhibitory activity. The effects of extraction conditions and extraction solvent fractions on α-glucosidase inhibitory activity of Sargassum mcclurei were investigated. The suitable extraction conditions were found to be the solid to liquid ratio (g/mL) of 1/40, the extraction time of 60 min and the extraction temperature of 60oC. The ethyl acetate extracted fraction showed the highest α-glucosidase inhibitory activity compared with other fractions.

Keywords: α-glucosidase inhibitor, Brown seaweeds, Diabetic, Extraction conditions, Sargassum mcclurei

Article Details

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