A field study on the evaluation of application of MB-1® live attenuated vaccine in broilers
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Abstract
The research aimed to evaluate the application of MB-1 vaccine at the hatchery to prevent Gumboro disease in commercial broilers. One hundred serum samples were randomly collected from commercial white broilers to examine infectious bursal disease virus (IBDV) and Newcastle disease virus (NDV) antibody titers. The surveyed chickens exhibited an average maternally derived antibody (MDA) level of 3,258 ± 1,551 (titers). At 36 and 42 days of age, IBDV antibody titers exceeded the protection level, with very high uniformity: 4,217 ± 911 and 4,413 ± 1,153 (titers), respectively. In addition, the humoral immune response to the ND vaccine is good with antibody titers of 3,180 ± 2,103 at 42 days of age. IBDV of MB-1 vaccine was detected in bursa from 15 days of age and persisted until the last sample was taken at 36 days of age. The bursa lesion scores (BLS) were at normal ranges, gradually increasing from 1 to 2.8 between 18 and 36 days of age. The bursa index (BI) was highest when the chicken was at 15 days old (0.23%) and decreased to the lowest (0.06%) when the chicken was at 36 days old. In summary, the use of MB-1 vaccine in the hatchery has shown early localization of the MB-1 vaccine virus in the bursa, provided a strong immune response to IBDV without affecting the humoral immune response to the ND killed vaccine, and was safe for the bursa when applied to commercial broilers at the hatchery.
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References
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