Structure, function, and potential application of F18 in vaccine development

Uy H. G. Vu , Trang L. T. X. Le , & Hieu V. Tran *

* Correspondence: Tran Van Hieu (email: tvhieu@hcmus.edu.vn)

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Received: 18 May 2023
Revised: 03 Jul 2023
Accepted: 11 Jul 2023
Published: 23 Oct 2023
DOI: 10.52997/jad.5.05.2023
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Vu, U. H. G., Le, T. L. T. X., & Tran, H. V. (2023). Structure, function, and potential application of F18 in vaccine development. The Journal of Agriculture and Development 22(5), 47-56.
Issue
Volume 22 - Issue 5 (2023)
Section
Biotechnology

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Abstract

Post-weaning diarrhea is one of the most common diseases in pigs, affecting pigs in the first two weeks after weaning, causing significant economic losses. The main cause of this disease is Enterotoxigenic Escherichia coli (ETEC), which is characterized by two pathogenic factors: fimbriae and enterotoxins. These fimbriae are considered to mediate bacterial adhesion through binding to the receptor present in the pig intestine. Several studies indicate that F4 and F18 fimbriae account for a high percentage of the fimbriae in ETEC and are detected in most of the isolated ETEC strains. Currently, oral vaccines are a potential preventive measure used with the ability to generate IgA, stimulate the mucosal immune system, and be widely noticed by researchers. However, the vaccines are only effective against ETEC-F4 and less effective against ETEC-F18, so more research is needed to improve the effectiveness of ETEC-F18 vaccines in the future. In this review, we presented the structure, function, and potential application of the F18 in vaccine development.

Keywords: Enterotoxigenic Escherichia coli (ETEC) , F18 , FedF , Post-weaning diarrhea

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References

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